Experimental production of autoimmune aspermatogenic orchitis in the rabbit in consequence of in situ freezing of the testis

R. J. Ablin; W. A. Soanes

doi:10.1159/000127605

Experimental production of autoimmune aspermatogenic orchitis in the rabbit in consequence of in situ freezing of the testis

R. J. Ablin, W. A. Soanes

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Multiple in situ freezing of the rabbit testis has been shown to be an effective antigenic stimulus as evidenced from the production of tissue-specific antibodies against a testicular antigen. These antibodies reacted with isologous as well as autologous testicular extracts. Histologic studies of testicular biopsies of the contralateral testis of frozen animals revealed alterations similar to those described by others following the induction of experimental autoimmune aspermatogenic orchitis by parenteral administration of testicular extracts in other species. The possibility of the induction of controlled freezing injury of an organ may provide a useful experimental model for further studies of autoimmunity in man and in experimental animals.

Original language	English (US)
Pages (from-to)	98-106
Number of pages	9
Journal	European Surgical Research
Volume	4
Issue number	2
DOIs	https://doi.org/10.1159/000127605
State	Published - 1972
Externally published	Yes

Keywords

Aspermatogenesis
Autoantibodies to testes
Autoimmune orchitis
Autosensitization
In situ freezing of testes

ASJC Scopus subject areas

Surgery

Access to Document

10.1159/000127605

Cite this

@article{f6454132754747ce9c763528d66d0284,

title = "Experimental production of autoimmune aspermatogenic orchitis in the rabbit in consequence of in situ freezing of the testis",

abstract = "Multiple in situ freezing of the rabbit testis has been shown to be an effective antigenic stimulus as evidenced from the production of tissue-specific antibodies against a testicular antigen. These antibodies reacted with isologous as well as autologous testicular extracts. Histologic studies of testicular biopsies of the contralateral testis of frozen animals revealed alterations similar to those described by others following the induction of experimental autoimmune aspermatogenic orchitis by parenteral administration of testicular extracts in other species. The possibility of the induction of controlled freezing injury of an organ may provide a useful experimental model for further studies of autoimmunity in man and in experimental animals.",

keywords = "Aspermatogenesis, Autoantibodies to testes, Autoimmune orchitis, Autosensitization, In situ freezing of testes",

author = "Ablin, {R. J.} and Soanes, {W. A.}",

year = "1972",

doi = "10.1159/000127605",

language = "English (US)",

volume = "4",

pages = "98--106",

journal = "European Surgical Research",

issn = "0014-312X",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Experimental production of autoimmune aspermatogenic orchitis in the rabbit in consequence of in situ freezing of the testis

AU - Ablin, R. J.

AU - Soanes, W. A.

PY - 1972

Y1 - 1972

N2 - Multiple in situ freezing of the rabbit testis has been shown to be an effective antigenic stimulus as evidenced from the production of tissue-specific antibodies against a testicular antigen. These antibodies reacted with isologous as well as autologous testicular extracts. Histologic studies of testicular biopsies of the contralateral testis of frozen animals revealed alterations similar to those described by others following the induction of experimental autoimmune aspermatogenic orchitis by parenteral administration of testicular extracts in other species. The possibility of the induction of controlled freezing injury of an organ may provide a useful experimental model for further studies of autoimmunity in man and in experimental animals.

AB - Multiple in situ freezing of the rabbit testis has been shown to be an effective antigenic stimulus as evidenced from the production of tissue-specific antibodies against a testicular antigen. These antibodies reacted with isologous as well as autologous testicular extracts. Histologic studies of testicular biopsies of the contralateral testis of frozen animals revealed alterations similar to those described by others following the induction of experimental autoimmune aspermatogenic orchitis by parenteral administration of testicular extracts in other species. The possibility of the induction of controlled freezing injury of an organ may provide a useful experimental model for further studies of autoimmunity in man and in experimental animals.

KW - Aspermatogenesis

KW - Autoantibodies to testes

KW - Autoimmune orchitis

KW - Autosensitization

KW - In situ freezing of testes

UR - http://www.scopus.com/inward/record.url?scp=0015268186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015268186&partnerID=8YFLogxK

U2 - 10.1159/000127605

DO - 10.1159/000127605

M3 - Article

C2 - 5042927

AN - SCOPUS:0015268186

SN - 0014-312X

VL - 4

SP - 98

EP - 106

JO - European Surgical Research

JF - European Surgical Research

IS - 2

ER -

Experimental production of autoimmune aspermatogenic orchitis in the rabbit in consequence of in situ freezing of the testis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this