Experimental orthotopic tracheal transplantation: The Stanford technique

Sonja Schrepfer; Tobias Deuse; Grant Hoyt; Ahmad Y. Sheikh; Joerg Hoffmann; Hermann Reichenspurner; Robert C. Robbins; Marc P. Pelletier

doi:10.1002/micr.20329

Experimental orthotopic tracheal transplantation: The Stanford technique

Sonja Schrepfer, Tobias Deuse, Grant Hoyt, Ahmad Y. Sheikh, Joerg Hoffmann, Hermann Reichenspurner, Robert C. Robbins, Marc P. Pelletier

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The rat heterotopic tracheal transplantation model is widely used as an experimental model to study the development of obliterative airway disease (OAD) and to assess immunosuppressive strategies for chronic rejection. Despite its widespread application, the heterotopic transplantation model does have a number of limitations like the lack of air flow and mucociliary clearance. The present article provides a detailed description of the surgical technique for orthotopic tracheal transplantations, which may share more similarities with lung transplants in humans. The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis.

Original language	English (US)
Pages (from-to)	187-189
Number of pages	3
Journal	Microsurgery
Volume	27
Issue number	3
DOIs	https://doi.org/10.1002/micr.20329
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Surgery

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title = "Experimental orthotopic tracheal transplantation: The Stanford technique",

abstract = "The rat heterotopic tracheal transplantation model is widely used as an experimental model to study the development of obliterative airway disease (OAD) and to assess immunosuppressive strategies for chronic rejection. Despite its widespread application, the heterotopic transplantation model does have a number of limitations like the lack of air flow and mucociliary clearance. The present article provides a detailed description of the surgical technique for orthotopic tracheal transplantations, which may share more similarities with lung transplants in humans. The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis.",

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AU - Schrepfer, Sonja

AU - Deuse, Tobias

AU - Hoyt, Grant

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AU - Hoffmann, Joerg

AU - Reichenspurner, Hermann

AU - Robbins, Robert C.

AU - Pelletier, Marc P.

PY - 2007

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AB - The rat heterotopic tracheal transplantation model is widely used as an experimental model to study the development of obliterative airway disease (OAD) and to assess immunosuppressive strategies for chronic rejection. Despite its widespread application, the heterotopic transplantation model does have a number of limitations like the lack of air flow and mucociliary clearance. The present article provides a detailed description of the surgical technique for orthotopic tracheal transplantations, which may share more similarities with lung transplants in humans. The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis.

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Experimental orthotopic tracheal transplantation: The Stanford technique

Abstract

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