Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

Joao Luis Carvalho-de-Souza, Andrea Saponaro, C. A.Z. Bassetto, Oliver Rauh, Indra Schroeder, Fabio Franciolini, Luigi Catacuzzeno, Francisco Bezanilla, Gerhard Thiel, Anna Moroni

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.

Original languageEnglish (US)
Article number1978317
JournalAdvances in Physics: X
Volume7
Issue number1
DOIs
StatePublished - 2022
Externally publishedYes

Keywords

  • K channel
  • gating
  • intramolecular communication
  • selectivity filter
  • voltage sensor

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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