Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Michael Umkehrer, Günther Ross, Nadine Jäger, Christoph Burdack, Jürgen Kolb, Hong Hu, Maria Alvim-Gaston, Christopher Hulme

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalTetrahedron Letters
Issue number12
StatePublished - Mar 19 2007


  • Combinatorial chemistry
  • Imidazo[1,2-c]pyrimidines
  • Three component condensation (3CC)
  • [4+1]-Cycloaddition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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