Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Michael Umkehrer; Günther Ross; Nadine Jäger; Christoph Burdack; Jürgen Kolb; Hong Hu; Maria Alvim-Gaston; Christopher Hulme

doi:10.1016/j.tetlet.2007.01.061

Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Michael Umkehrer, Günther Ross, Nadine Jäger, Christoph Burdack, Jürgen Kolb, Hong Hu, Maria Alvim-Gaston, Christopher Hulme

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

Original language	English (US)
Pages (from-to)	2213-2216
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	12
DOIs	https://doi.org/10.1016/j.tetlet.2007.01.061
State	Published - Mar 19 2007
Externally published	Yes

Keywords

Combinatorial chemistry
Imidazo[1,2-c]pyrimidines
Three component condensation (3CC)
[4+1]-Cycloaddition

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.01.061

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abstract = "A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.",

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T1 - Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

AU - Umkehrer, Michael

AU - Ross, Günther

AU - Jäger, Nadine

AU - Burdack, Christoph

AU - Kolb, Jürgen

AU - Hu, Hong

AU - Alvim-Gaston, Maria

AU - Hulme, Christopher

PY - 2007/3/19

Y1 - 2007/3/19

N2 - A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

AB - A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure.

KW - Combinatorial chemistry

KW - Imidazo[1,2-c]pyrimidines

KW - Three component condensation (3CC)

KW - [4+1]-Cycloaddition

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ER -

Expeditious synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition

Abstract

Keywords

ASJC Scopus subject areas

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