Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

Zhiyun Du; Chenggang Zhou; Yaojun Gao; Qiao Ren; Kun Zhang; Hansong Cheng; Wei Wang; Jian Wang

doi:10.1039/c1ob06497e

Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

Zhiyun Du
, Chenggang Zhou
, Yaojun Gao
, Qiao Ren
, Kun Zhang
, Hansong Cheng
, Wei Wang
, Jian Wang

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.

Original language	English (US)
Pages (from-to)	36-39
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	1
DOIs	https://doi.org/10.1039/c1ob06497e
State	Published - Jan 7 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.",

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AU - Du, Zhiyun

AU - Zhou, Chenggang

AU - Gao, Yaojun

AU - Ren, Qiao

AU - Zhang, Kun

AU - Cheng, Hansong

AU - Wang, Wei

AU - Wang, Jian

PY - 2012/1/7

Y1 - 2012/1/7

N2 - An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.

AB - An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.

UR - https://www.scopus.com/pages/publications/82955223270

UR - https://www.scopus.com/pages/publications/82955223270#tab=citedBy

U2 - 10.1039/c1ob06497e

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AN - SCOPUS:82955223270

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ER -

Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

Abstract

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