Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

Zhiyun Du, Chenggang Zhou, Yaojun Gao, Qiao Ren, Kun Zhang, Hansong Cheng, Wei Wang, Jian Wang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number1
DOIs
StatePublished - Jan 7 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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