Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats

C. A. Barnes, M. J. Forster, M. Fleshner, E. N. Ahanotu, M. L. Laudenslager, R. S. Mazzeo, S. F. Maier, H. Lal

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Old F-344 rats were given endurance training over a 10-week period on a motorized treadmill. This treatment resulted in substantial heart-to-body weight ratio increases, indicative of effective training. To determine whether endurance training might alter some of the known immune system and cognitive changes observed during aging, exercised old rats were compared to nonexercised old and young controls on three variables: in vivo antigen-specific immune activity, brain-reactive antibody formation, and spatial memory. The exercise training did not influence any of these measures in the old rats. Both groups of old rats showed poorer antibody response to a specific antigen, more brain-reactive antibody formation, and poorer spatial memory than the young controls. There was, however, a significant relationship between brain-reactive antibody formation and spatial memory performance, regardless of training condition.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalNeurobiology of Aging
Issue number1
StatePublished - 1991


  • Autoimmunity
  • Brain-reactive antibodies
  • Exercise and aging
  • KLH serum antibodies
  • Spatial memory

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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