Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)

Kathryn H. Schmitz; Justin C. Brown; Melinda L. Irwin; Kim Robien; Jessica M. Scott; Nathan A. Berger; Bette Caan; Andrea Cercek; Tracy E. Crane; Scott R. Evans; Jennifer A. Ligibel; Jeffrey A. Meyerhardt; Tanya Agurs-Collins; Karen Basen-Engquist; Jennifer W. Bea; Sheng F. Cai; Brenda Cartmel; Vernon M. Chinchilli; Wendy Demark-Wahnefried; Christina M. Dieli-Conwright; Loretta DiPietro; Shawna E. Doerksen; Sharon L. Edelstein; Joanne Elena; William Evans; Leah M. Ferrucci; Julia Foldi; Sarah Freylersythe; Helena Furberg; Lee W. Jones; Ross Levine; Chaya S. Moskowitz; Cynthia Owusu; Frank Penedo; Borsika A. Rabin; Elena Ratner; Margaret Rosenzweig; Talya Salz; Tara Sanft; Matthew Schlumbrecht; Guillaume Spielmann; Cynthia A. Thomson; Ashley H. Tjaden; Martin R. Weiser; Shengping Yang; Anthony F. Yu; Frank M. Perna

doi:10.1093/jnci/djae177

Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)

Kathryn H. Schmitz, Justin C. Brown, Melinda L. Irwin, Kim Robien, Jessica M. Scott, Nathan A. Berger, Bette Caan, Andrea Cercek, Tracy E. Crane, Scott R. Evans, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Tanya Agurs-Collins, Karen Basen-Engquist, Jennifer W. Bea, Sheng F. Cai, Brenda Cartmel, Vernon M. Chinchilli, Wendy Demark-Wahnefried, Christina M. Dieli-ConwrightLoretta DiPietro, Shawna E. Doerksen, Sharon L. Edelstein, Joanne Elena, William Evans, Leah M. Ferrucci, Julia Foldi, Sarah Freylersythe, Helena Furberg, Lee W. Jones, Ross Levine, Chaya S. Moskowitz, Cynthia Owusu, Frank Penedo, Borsika A. Rabin, Elena Ratner, Margaret Rosenzweig, Talya Salz, Tara Sanft, Matthew Schlumbrecht, Guillaume Spielmann, Cynthia A. Thomson, Ashley H. Tjaden, Martin R. Weiser, Shengping Yang, Anthony F. Yu, Frank M. Perna

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.

Original language	English (US)
Pages (from-to)	9-19
Number of pages	11
Journal	Journal of the National Cancer Institute
Volume	117
Issue number	1
DOIs	https://doi.org/10.1093/jnci/djae177
State	Published - Jan 1 2025

ASJC Scopus subject areas

Oncology
Cancer Research

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Schmitz, K. H., Brown, J. C., Irwin, M. L., Robien, K., Scott, J. M., Berger, N. A., Caan, B., Cercek, A., Crane, T. E., Evans, S. R., Ligibel, J. A., Meyerhardt, J. A., Agurs-Collins, T., Basen-Engquist, K., Bea, J. W., Cai, S. F., Cartmel, B., Chinchilli, V. M., Demark-Wahnefried, W., ... Perna, F. M. (2025). Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO). Journal of the National Cancer Institute, 117(1), 9-19. https://doi.org/10.1093/jnci/djae177

Schmitz, KH, Brown, JC, Irwin, ML, Robien, K, Scott, JM, Berger, NA, Caan, B, Cercek, A, Crane, TE, Evans, SR, Ligibel, JA, Meyerhardt, JA, Agurs-Collins, T, Basen-Engquist, K, Bea, JW, Cai, SF, Cartmel, B, Chinchilli, VM, Demark-Wahnefried, W, Dieli-Conwright, CM, DiPietro, L, Doerksen, SE, Edelstein, SL, Elena, J, Evans, W, Ferrucci, LM, Foldi, J, Freylersythe, S, Furberg, H, Jones, LW, Levine, R, Moskowitz, CS, Owusu, C, Penedo, F, Rabin, BA, Ratner, E, Rosenzweig, M, Salz, T, Sanft, T, Schlumbrecht, M, Spielmann, G, Thomson, CA, Tjaden, AH, Weiser, MR, Yang, S, Yu, AF & Perna, FM 2025, 'Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)', Journal of the National Cancer Institute, vol. 117, no. 1, pp. 9-19. https://doi.org/10.1093/jnci/djae177

@article{5c296466d8db49bb9764329e6903b80c,

title = "Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)",

abstract = "Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project{\textquoteright}s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.",

author = "Schmitz, {Kathryn H.} and Brown, {Justin C.} and Irwin, {Melinda L.} and Kim Robien and Scott, {Jessica M.} and Berger, {Nathan A.} and Bette Caan and Andrea Cercek and Crane, {Tracy E.} and Evans, {Scott R.} and Ligibel, {Jennifer A.} and Meyerhardt, {Jeffrey A.} and Tanya Agurs-Collins and Karen Basen-Engquist and Bea, {Jennifer W.} and Cai, {Sheng F.} and Brenda Cartmel and Chinchilli, {Vernon M.} and Wendy Demark-Wahnefried and Dieli-Conwright, {Christina M.} and Loretta DiPietro and Doerksen, {Shawna E.} and Edelstein, {Sharon L.} and Joanne Elena and William Evans and Ferrucci, {Leah M.} and Julia Foldi and Sarah Freylersythe and Helena Furberg and Jones, {Lee W.} and Ross Levine and Moskowitz, {Chaya S.} and Cynthia Owusu and Frank Penedo and Rabin, {Borsika A.} and Elena Ratner and Margaret Rosenzweig and Talya Salz and Tara Sanft and Matthew Schlumbrecht and Guillaume Spielmann and Thomson, {Cynthia A.} and Tjaden, {Ashley H.} and Weiser, {Martin R.} and Shengping Yang and Yu, {Anthony F.} and Perna, {Frank M.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2025",

month = jan,

day = "1",

doi = "10.1093/jnci/djae177",

language = "English (US)",

volume = "117",

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T1 - Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)

AU - Schmitz, Kathryn H.

AU - Brown, Justin C.

AU - Irwin, Melinda L.

AU - Robien, Kim

AU - Scott, Jessica M.

AU - Berger, Nathan A.

AU - Caan, Bette

AU - Cercek, Andrea

AU - Crane, Tracy E.

AU - Evans, Scott R.

AU - Ligibel, Jennifer A.

AU - Meyerhardt, Jeffrey A.

AU - Agurs-Collins, Tanya

AU - Basen-Engquist, Karen

AU - Bea, Jennifer W.

AU - Cai, Sheng F.

AU - Cartmel, Brenda

AU - Chinchilli, Vernon M.

AU - Demark-Wahnefried, Wendy

AU - Dieli-Conwright, Christina M.

AU - DiPietro, Loretta

AU - Doerksen, Shawna E.

AU - Edelstein, Sharon L.

AU - Elena, Joanne

AU - Evans, William

AU - Ferrucci, Leah M.

AU - Foldi, Julia

AU - Freylersythe, Sarah

AU - Furberg, Helena

AU - Jones, Lee W.

AU - Levine, Ross

AU - Moskowitz, Chaya S.

AU - Owusu, Cynthia

AU - Penedo, Frank

AU - Rabin, Borsika A.

AU - Ratner, Elena

AU - Rosenzweig, Margaret

AU - Salz, Talya

AU - Sanft, Tara

AU - Schlumbrecht, Matthew

AU - Spielmann, Guillaume

AU - Thomson, Cynthia A.

AU - Tjaden, Ashley H.

AU - Weiser, Martin R.

AU - Yang, Shengping

AU - Yu, Anthony F.

AU - Perna, Frank M.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.

AB - Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.

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U2 - 10.1093/jnci/djae177

DO - 10.1093/jnci/djae177

M3 - Review article

C2 - 39118255

AN - SCOPUS:85214824650

SN - 0027-8874

VL - 117

SP - 9

EP - 19

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 1

ER -

Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)

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