Excitability Changes in Hippocampal Granule Cells of Senescent Rat

C. A. Barnes, B. L. McNaughton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Research on senescent nervous systems has tended to emphasize processes of deterioration, which may be among the most obvious and important kinds of alterations to occur over the lifespan. A number of recent findings, however, suggest that preservation of function, in spite of deteriorative change, occurs at many levels of the nervous system. One example of a seemingly compensatory change in senescent rat brain function is an increased electrical excitability of hippocampal granule cells in the face of a considerable reduction in the afferent fiber population. This chapter examines one possible mechanism of this change.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalProgress in Brain Research
Issue numberC
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • General Neuroscience


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