Abstract
Pandemics originating from non-human animals highlight the need to understand how natural hosts have evolved in response to emerging human pathogens and which groups may be susceptible to infection and/or potential reservoirs to mitigate public health and conservation concerns. Multiple zoonotic coronaviruses, such as severe acute respiratory syndrome-associated coronavirus (SARS-CoV), SARS-CoV-2 and Middle Eastern respiratory syndrome-associated coronavirus (MERS-CoV), are hypothesized to have evolved in bats. We investigate angiotensin-converting enzyme 2 (ACE2), the host protein bound by SARS-CoV and SARS-CoV-2, and dipeptidyl-peptidase 4 (DPP4 or CD26), the host protein bound by MERS-CoV, in the largest bat datasets to date. Both the ACE2 and DPP4 genes are under strong selection pressure in bats, more so than in other mammals, and in residues that contact viruses. Additionally, mammalian groups vary in their similarity to humans in residues that contact SARS-CoV, SARS-CoV-2 and MERS-CoV, and increased similarity to humans in binding residues is broadly predictive of susceptibility to SARS-CoV-2. This work augments our understanding of the relationship between coronaviruses and mammals, particularly bats, provides taxonomically diverse data for studies of how host proteins are bound by coronaviruses and can inform surveillance, conservation and public health efforts.
Original language | English (US) |
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Article number | 20220193 |
Journal | Proceedings of the Royal Society B: Biological Sciences |
Volume | 289 |
Issue number | 1979 |
DOIs | |
State | Published - Jul 27 2022 |
Keywords
- ACE2
- COVID-19
- Chiroptera
- DPP4
- SARS-CoV-2
- molecular evolution
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Environmental Science(all)
- Agricultural and Biological Sciences(all)
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Supplementary tables, figures, captions, data, scripts from Exceptional diversity and selection pressure on coronavirus host receptors in bats compared to other mammals
Frank, H. K. (Creator), Enard, D. (Creator) & Boyd, S. D. (Creator), The Royal Society, 2022
DOI: 10.6084/m9.figshare.20237386, https://rs.figshare.com/articles/dataset/Supplementary_tables_figures_captions_data_scripts_from_Exceptional_diversity_and_selection_pressure_on_coronavirus_host_receptors_in_bats_compared_to_other_mammals/20237386
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Supplementary material from "Exceptional diversity and selection pressure on coronavirus host receptors in bats compared to other mammals"
Frank, H. K. (Creator), Enard, D. (Creator) & Boyd, S. D. (Creator), The Royal Society, 2022
DOI: 10.6084/m9.figshare.c.6080908, https://rs.figshare.com/collections/Supplementary_material_from_Exceptional_diversity_and_selection_pressure_on_coronavirus_host_receptors_in_bats_compared_to_other_mammals_/6080908
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Supplementary material from "Exceptional diversity and selection pressure on coronavirus host receptors in bats compared to other mammals"
Frank, H. K. (Creator), Enard, D. (Creator) & Boyd, S. D. (Creator), The Royal Society, 2022
DOI: 10.6084/m9.figshare.c.6080908.v1, https://rs.figshare.com/collections/Supplementary_material_from_Exceptional_diversity_and_selection_pressure_on_coronavirus_host_receptors_in_bats_compared_to_other_mammals_/6080908/1
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