TY - JOUR
T1 - Examination of Lens calcium balance using 45ca uptake studies
AU - Delamere, Nicholas A.
AU - Paterson, Christopher A.
N1 - Funding Information:
ACKNOWLEDGEMENTS This study was supported by USPHS research grant number EY 00506 from the National Eye Institute, National Institutes of Health.
PY - 1985
Y1 - 1985
N2 - The utility of Ca efflux studies to examine lens calcium balance is limited because of the dominant contribution of efflux from the extracellular space of the lens. On the other hand, examination of lens "Ca uptake characteristics can generate valuable information regarding the mechanism by which calcium is largely restricted from the intracellular compartment. Such studies have enabled us to demonstrate that the access of calcium to the intracellular compartment is dependent to some extent upon the concentration of calcium in the extracellular environment. Additionally, experimental evidence speaks against extracellular binding of calcium. Finally, lens membrane permeability to calcium appears to be independent of membrane voltage.
AB - The utility of Ca efflux studies to examine lens calcium balance is limited because of the dominant contribution of efflux from the extracellular space of the lens. On the other hand, examination of lens "Ca uptake characteristics can generate valuable information regarding the mechanism by which calcium is largely restricted from the intracellular compartment. Such studies have enabled us to demonstrate that the access of calcium to the intracellular compartment is dependent to some extent upon the concentration of calcium in the extracellular environment. Additionally, experimental evidence speaks against extracellular binding of calcium. Finally, lens membrane permeability to calcium appears to be independent of membrane voltage.
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U2 - 10.3109/02713688509025159
DO - 10.3109/02713688509025159
M3 - Article
C2 - 4017634
AN - SCOPUS:0021928564
SN - 0271-3683
VL - 4
SP - 447
EP - 452
JO - Current Eye Research
JF - Current Eye Research
IS - 4
ER -