## Abstract

Evolutionary capacitors phenotypically reveal a stock of cryptic genetic variation in a reversible fashion. The sudden and reversible revelation of a range of variation is fundamentally different from the gradual introduction of variation by mutation. Here I study the invasion dynamics of modifiers of revelation. A modifier with the optimal rate of revelation m_{opt} has a higher probability of invading any other population than of being counterinvaded. m_{opt} varies with the population size N and the rate θ at which environmental change makes revelation adaptive. For small populations less than a minimum cutoff N_{min}, all revelation is selected against. N_{min} is typically quite small and increases only weakly, with θ^{-1/2}. For large populations with N > 1/θ, m_{opt} is ∼1/N. Selection for the optimum is highly effective and increases in effectiveness with larger N ≫ 1/θ. For intermediate values of N, m_{opt} is typically a little less than θ and is only weakly favored over less frequent revelation. The model is analogous to a two-locus model for the evolution of a mutator allele. It is a fully stochastic model and so is able to show that selection for revelation can be strong enough to overcome random drift.

Original language | English (US) |
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Pages (from-to) | 1359-1371 |

Number of pages | 13 |

Journal | Genetics |

Volume | 170 |

Issue number | 3 |

DOIs | |

State | Published - Jul 2005 |

## ASJC Scopus subject areas

- Genetics