TY - JOUR
T1 - Evolution of the pseudoautosomal boundary in old world monkeys and great apes
AU - Ellis, Nathan
AU - Yen, Pauline
AU - Neiswanger, Katherine
AU - Shapiro, Larry J.
AU - Goodfellow, Peter N.
N1 - Funding Information:
We would like to thank Glare Middlemiss for preparation of the manuscript and Drs. Rosalind Harding and Sue Povey for careful reading and discussion. R Y. and L. J. S. are supported by funds from Howard Hughes Medical Institute and NIH grant HD 12178.
PY - 1990/11/30
Y1 - 1990/11/30
N2 - Mammalian sex chromosomes are divided into sex-specific and pseudoautosomal regions. Sequences in the pseudoautosomal region recombine between the sex chromosomes; the sex-specific sequences normally do not. The interface between sex-specific and pseudoautosomal sequences is the pseudoautosomal boundary. The boundary is the centromeric limit to recombination in the pseudoautosomal region. In man, an Alu repeat element is found inserted at the boundary on the Y chromosome. In the evolutionary comparison conducted here, the Alu repeat element is found at the Y boundary in great apes, but it is not found there in two Old World monkeys. During the evolution of the Old World monkey and great ape lineages, homology between the sex chromosomes was maintained by recombination in the sequences telomeric to the Alu insertion site. The Alu repeat element did not create the present-day boundary; instead, it inserted at the preexisting boundary after the Old World monkey and great ape lineages diverged.
AB - Mammalian sex chromosomes are divided into sex-specific and pseudoautosomal regions. Sequences in the pseudoautosomal region recombine between the sex chromosomes; the sex-specific sequences normally do not. The interface between sex-specific and pseudoautosomal sequences is the pseudoautosomal boundary. The boundary is the centromeric limit to recombination in the pseudoautosomal region. In man, an Alu repeat element is found inserted at the boundary on the Y chromosome. In the evolutionary comparison conducted here, the Alu repeat element is found at the Y boundary in great apes, but it is not found there in two Old World monkeys. During the evolution of the Old World monkey and great ape lineages, homology between the sex chromosomes was maintained by recombination in the sequences telomeric to the Alu insertion site. The Alu repeat element did not create the present-day boundary; instead, it inserted at the preexisting boundary after the Old World monkey and great ape lineages diverged.
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U2 - 10.1016/0092-8674(90)90501-5
DO - 10.1016/0092-8674(90)90501-5
M3 - Article
C2 - 2124175
AN - SCOPUS:0025651769
SN - 0092-8674
VL - 63
SP - 977
EP - 986
JO - Cell
JF - Cell
IS - 5
ER -