Evolution of CST function in telomere maintenance

Carolyn M. Price; Kara A. Boltz; Mary F. Chaiken; Jason A. Stewart; Mark A. Beilstein; Dorothy E. Shippen

doi:10.4161/cc.9.16.12547

Evolution of CST function in telomere maintenance

Carolyn M. Price, Kara A. Boltz, Mary F. Chaiken, Jason A. Stewart, Mark A. Beilstein, Dorothy E. Shippen

Research output: Contribution to journal › Review article › peer-review

139 Scopus citations

Abstract

Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.

Original language	English (US)
Pages (from-to)	3177-3185
Number of pages	9
Journal	Cell Cycle
Volume	9
Issue number	16
DOIs	https://doi.org/10.4161/cc.9.16.12547
State	Published - Aug 15 2010
Externally published	Yes

Keywords

Arabidopsis
CTC1
DNA polymerase alpha
OB-fold
RPA
STN1
TEN1
Telomerase
Telomere
Telomere protein

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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title = "Evolution of CST function in telomere maintenance",

abstract = "Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.",

keywords = "Arabidopsis, CTC1, DNA polymerase alpha, OB-fold, RPA, STN1, TEN1, Telomerase, Telomere, Telomere protein",

author = "Price, {Carolyn M.} and Boltz, {Kara A.} and Chaiken, {Mary F.} and Stewart, {Jason A.} and Beilstein, {Mark A.} and Shippen, {Dorothy E.}",

note = "Funding Information: Work from our labs is supported by NIH grants GM065383 (D.E.S.), GM041803 (C.M.P.), GM088728 (C.M.P), NSF grant MCB-0843399 (D.E.S.) and Ruth L. Kirschstein National Research Service Awards F32 CA117846 ( J.A.S.) and F32 GM093635 (M.A.B.).",

year = "2010",

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doi = "10.4161/cc.9.16.12547",

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AU - Price, Carolyn M.

AU - Boltz, Kara A.

AU - Chaiken, Mary F.

AU - Stewart, Jason A.

AU - Beilstein, Mark A.

AU - Shippen, Dorothy E.

N1 - Funding Information: Work from our labs is supported by NIH grants GM065383 (D.E.S.), GM041803 (C.M.P.), GM088728 (C.M.P), NSF grant MCB-0843399 (D.E.S.) and Ruth L. Kirschstein National Research Service Awards F32 CA117846 ( J.A.S.) and F32 GM093635 (M.A.B.).

PY - 2010/8/15

Y1 - 2010/8/15

N2 - Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.

AB - Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.

KW - Arabidopsis

KW - CTC1

KW - DNA polymerase alpha

KW - OB-fold

KW - RPA

KW - STN1

KW - TEN1

KW - Telomerase

KW - Telomere

KW - Telomere protein

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SN - 1538-4101

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Evolution of CST function in telomere maintenance

Abstract

Keywords

ASJC Scopus subject areas

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