Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic

Ana Paula Streling; Mohanad M. Al Obaidi; William D. Lainhart; Tirdad Zangeneh; Ayesha Khan; An Q. Dinh; Blake Hanson; Cesar A. Arias; William R. Miller

doi:10.1093/cid/ciaa1909

Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic

Ana Paula Streling, Mohanad M. Al Obaidi, William D. Lainhart, Tirdad Zangeneh, Ayesha Khan, An Q. Dinh, Blake Hanson, Cesar A. Arias, William R. Miller

Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.

Original language	English (US)
Pages (from-to)	E4472-E4474
Journal	Clinical Infectious Diseases
Volume	73
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciaa1909
State	Published - Dec 1 2021

Keywords

Pseudomonas aeruginosa
antibiotic resistance
cefiderocol

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciaa1909

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title = "Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic",

abstract = "We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.",

keywords = "Pseudomonas aeruginosa, antibiotic resistance, cefiderocol",

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AU - Streling, Ana Paula

AU - Al Obaidi, Mohanad M.

AU - Lainhart, William D.

AU - Zangeneh, Tirdad

AU - Khan, Ayesha

AU - Dinh, An Q.

AU - Hanson, Blake

AU - Arias, Cesar A.

AU - Miller, William R.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.

AB - We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.

KW - Pseudomonas aeruginosa

KW - antibiotic resistance

KW - cefiderocol

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Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic

Abstract

Keywords

ASJC Scopus subject areas

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