Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic

Ana Paula Streling, Mohanad M. Al Obaidi, William D. Lainhart, Tirdad Zangeneh, Ayesha Khan, An Q. Dinh, Blake Hanson, Cesar A. Arias, William R. Miller

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.

Original languageEnglish (US)
Pages (from-to)e4472-e4474
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume73
Issue number11
DOIs
StatePublished - Dec 6 2021

Keywords

  • Pseudomonas aeruginosa
  • antibiotic resistance
  • cefiderocol

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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