Evidence for vasoactive intestinal polypeptide as a neurotransmitter in smooth muscle of the urogenital tract

J. C. Hunter; J. E. Maggio; P. W. Mantyh

doi:10.1016/0006-8993(84)90428-1

Evidence for vasoactive intestinal polypeptide as a neurotransmitter in smooth muscle of the urogenital tract

J. C. Hunter, J. E. Maggio, P. W. Mantyh

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The localization of vasoactive intestinal polypeptide (VIP) in the anococcygeus muscle of the rat, rabbit and cat was investigated by radioimmunoassay and immunohistochemistry. High concentrations of VIP-like immunoreactivity were found in the anococcygeus muscle of all 3 species. VIP-like immunoreactivity was observed in a network of nerve fibres branching throughout the muscle which were unaffected by treatment with 6-hydroxydopamine. VIP, when applied exogenously to isolated preparations of the anococcygeus, produced dose-related relaxations of tone in all 3 species with a time course and maximum response similar to non-adrenergic, non-cholinergic inhibitory nerve stimulation. These observations provide further evidence in support of VIP as a suitable candidate for the non-adrenergic, non-cholinergic inhibitory neurotransmitter in the anococcygeus muscle.

Original language	English (US)
Pages (from-to)	221-229
Number of pages	9
Journal	Brain Research
Volume	305
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90428-1
State	Published - Jul 9 1984
Externally published	Yes

Keywords

anococcygeus muscle
non-adrenergic, non-cholinergic inhibitory nerves
vasoactive intestinal polypeptide

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90428-1

Cite this

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title = "Evidence for vasoactive intestinal polypeptide as a neurotransmitter in smooth muscle of the urogenital tract",

abstract = "The localization of vasoactive intestinal polypeptide (VIP) in the anococcygeus muscle of the rat, rabbit and cat was investigated by radioimmunoassay and immunohistochemistry. High concentrations of VIP-like immunoreactivity were found in the anococcygeus muscle of all 3 species. VIP-like immunoreactivity was observed in a network of nerve fibres branching throughout the muscle which were unaffected by treatment with 6-hydroxydopamine. VIP, when applied exogenously to isolated preparations of the anococcygeus, produced dose-related relaxations of tone in all 3 species with a time course and maximum response similar to non-adrenergic, non-cholinergic inhibitory nerve stimulation. These observations provide further evidence in support of VIP as a suitable candidate for the non-adrenergic, non-cholinergic inhibitory neurotransmitter in the anococcygeus muscle.",

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T1 - Evidence for vasoactive intestinal polypeptide as a neurotransmitter in smooth muscle of the urogenital tract

AU - Hunter, J. C.

AU - Maggio, J. E.

AU - Mantyh, P. W.

PY - 1984/7/9

Y1 - 1984/7/9

N2 - The localization of vasoactive intestinal polypeptide (VIP) in the anococcygeus muscle of the rat, rabbit and cat was investigated by radioimmunoassay and immunohistochemistry. High concentrations of VIP-like immunoreactivity were found in the anococcygeus muscle of all 3 species. VIP-like immunoreactivity was observed in a network of nerve fibres branching throughout the muscle which were unaffected by treatment with 6-hydroxydopamine. VIP, when applied exogenously to isolated preparations of the anococcygeus, produced dose-related relaxations of tone in all 3 species with a time course and maximum response similar to non-adrenergic, non-cholinergic inhibitory nerve stimulation. These observations provide further evidence in support of VIP as a suitable candidate for the non-adrenergic, non-cholinergic inhibitory neurotransmitter in the anococcygeus muscle.

AB - The localization of vasoactive intestinal polypeptide (VIP) in the anococcygeus muscle of the rat, rabbit and cat was investigated by radioimmunoassay and immunohistochemistry. High concentrations of VIP-like immunoreactivity were found in the anococcygeus muscle of all 3 species. VIP-like immunoreactivity was observed in a network of nerve fibres branching throughout the muscle which were unaffected by treatment with 6-hydroxydopamine. VIP, when applied exogenously to isolated preparations of the anococcygeus, produced dose-related relaxations of tone in all 3 species with a time course and maximum response similar to non-adrenergic, non-cholinergic inhibitory nerve stimulation. These observations provide further evidence in support of VIP as a suitable candidate for the non-adrenergic, non-cholinergic inhibitory neurotransmitter in the anococcygeus muscle.

KW - anococcygeus muscle

KW - non-adrenergic, non-cholinergic inhibitory nerves

KW - vasoactive intestinal polypeptide

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Evidence for vasoactive intestinal polypeptide as a neurotransmitter in smooth muscle of the urogenital tract

Abstract

Keywords

ASJC Scopus subject areas

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