Abstract
The distribution of cholecystokinin-like immunoreactive (CCK-LI) neurons has been mapped in the rat medulla after local and intracerebroventricular colchicine injections. CCK-positive neurons were found in the nucleus raphe magnus, nucleus raphe pallidus, nucleus raphe obscurus, nucleus paragigantocellularis pars α, and a population of ventral medullary neurons. Combined retrograde tracing with the fluorescent dye True Blue and indirect immunofluorescence for visualizing CCK neurons suggested that there was a CCK-LI system originating in the medulla and projecting to the spinal cord. Additional double labelling experiments established that some of these CCK-LI containing neurons also contain 5-HT.
Original language | English (US) |
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Pages (from-to) | 49-54 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 291 |
Issue number | 1 |
DOIs | |
State | Published - Jan 16 1984 |
Keywords
- 5-HT
- True Blue
- cholecystokinin
- coexistence
- medulla
- raphe
- spinal cord
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology