Evidence for a role for DNA polymerase β in mammalian meiosis

Annemieke W. Plug, Caroline A. Clairmont, Eva Sapi, Terry Ashley, Joann B. Sweasy

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

DNA polymerase β (pol β) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol β is not believed to participate in the replication of genomic DNA, several studies have indicated a role for phi β in DNA repair. The high level of expression of pol β in mouse and rat testes raises the possibility that pol β participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol β antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol β participates in meiotic events associated with synapsis and recombination.

Original languageEnglish (US)
Pages (from-to)1327-1331
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number4
DOIs
StatePublished - Feb 18 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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