Abstract
DNA polymerase β (pol β) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol β is not believed to participate in the replication of genomic DNA, several studies have indicated a role for phi β in DNA repair. The high level of expression of pol β in mouse and rat testes raises the possibility that pol β participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol β antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol β participates in meiotic events associated with synapsis and recombination.
Original language | English (US) |
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Pages (from-to) | 1327-1331 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 94 |
Issue number | 4 |
DOIs | |
State | Published - Feb 18 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General