DNA polymerase β (pol β) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol β is not believed to participate in the replication of genomic DNA, several studies have indicated a role for phi β in DNA repair. The high level of expression of pol β in mouse and rat testes raises the possibility that pol β participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol β antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol β participates in meiotic events associated with synapsis and recombination.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Feb 18 1997|
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