Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex

G. Michael Blackburn; Gregory R.J. Thatcher; Mir Wais Hosseini; Jean Marie Lehn

doi:10.1016/S0040-4039(00)96208-7

Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex

G. Michael Blackburn
, Gregory R.J. Thatcher
, Mir Wais Hosseini
, Jean Marie Lehn

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Analogues of ATP and diadenosine 5′,5″′-P₁,P₄-tetraphosphate, Ap₄A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [24]-N₆O₂ (1). The results show that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting from receptor-substrate binding.

Original language	English (US)
Pages (from-to)	2779-2782
Number of pages	4
Journal	Tetrahedron Letters
Volume	28
Issue number	24
DOIs	https://doi.org/10.1016/S0040-4039(00)96208-7
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex",

abstract = "Analogues of ATP and diadenosine 5′,5″′-P1,P4-tetraphosphate, Ap4A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [24]-N6O2 (1). The results show that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting from receptor-substrate binding.",

author = "Blackburn, \{G. Michael\} and Thatcher, \{Gregory R.J.\} and Hosseini, \{Mir Wais\} and Lehn, \{Jean Marie\}",

year = "1987",

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language = "English (US)",

volume = "28",

pages = "2779--2782",

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AU - Blackburn, G. Michael

AU - Thatcher, Gregory R.J.

AU - Hosseini, Mir Wais

AU - Lehn, Jean Marie

PY - 1987

Y1 - 1987

N2 - Analogues of ATP and diadenosine 5′,5″′-P1,P4-tetraphosphate, Ap4A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [24]-N6O2 (1). The results show that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting from receptor-substrate binding.

AB - Analogues of ATP and diadenosine 5′,5″′-P1,P4-tetraphosphate, Ap4A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [24]-N6O2 (1). The results show that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting from receptor-substrate binding.

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U2 - 10.1016/S0040-4039(00)96208-7

DO - 10.1016/S0040-4039(00)96208-7

M3 - Article

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IS - 24

ER -

Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex

Abstract

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