Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex

G. Michael Blackburn, Gregory R.J. Thatcher, Mir Wais Hosseini, Jean Marie Lehn

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Analogues of ATP and diadenosine 5′,5″′-P1,P4-tetraphosphate, Ap4A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [24]-N6O2 (1). The results show that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting from receptor-substrate binding.

Original languageEnglish (US)
Pages (from-to)2779-2782
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number24
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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