Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

Bao Li Chang; Elizabeth M. Gillanders; Sarah D. Isaacs; Kathy E. Wiley; Tamara Adams; Aubrey R. Turner; S. Lilly Zheng; Deborah A. Meyers; John D. Carpten; Patrick C. Walsh; Jeffrey M. Trent; Jianfeng Xu; William B. Isaacs

doi:10.1016/j.canlet.2004.10.005

Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

Bao Li Chang, Elizabeth M. Gillanders, Sarah D. Isaacs, Kathy E. Wiley, Tamara Adams, Aubrey R. Turner, S. Lilly Zheng, Deborah A. Meyers, John D. Carpten, Patrick C. Walsh, Jeffrey M. Trent, Jianfeng Xu, William B. Isaacs

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1 Scopus citations

Abstract

To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.

Original language	English (US)
Pages (from-to)	177-182
Number of pages	6
Journal	Cancer Letters
Volume	219
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2004.10.005
State	Published - Mar 10 2005
Externally published	Yes

Keywords

Cancer
Genome-wide scan
Hereditary
Linkage
Prostate cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2004.10.005

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Chang, B. L., Gillanders, E. M., Isaacs, S. D., Wiley, K. E., Adams, T., Turner, A. R., Zheng, S. L., Meyers, D. A., Carpten, J. D., Walsh, P. C., Trent, J. M., Xu, J., & Isaacs, W. B. (2005). Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer. Cancer Letters, 219(2), 177-182. https://doi.org/10.1016/j.canlet.2004.10.005

@article{3991f1a95e7d435fa3799aa6bb57eb01,

title = "Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer",

abstract = "To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.",

keywords = "Cancer, Genome-wide scan, Hereditary, Linkage, Prostate cancer",

author = "Chang, {Bao Li} and Gillanders, {Elizabeth M.} and Isaacs, {Sarah D.} and Wiley, {Kathy E.} and Tamara Adams and Turner, {Aubrey R.} and Zheng, {S. Lilly} and Meyers, {Deborah A.} and Carpten, {John D.} and Walsh, {Patrick C.} and Trent, {Jeffrey M.} and Jianfeng Xu and Isaacs, {William B.}",

note = "Funding Information: The authors thank all the study subjects who participated in this study. This work was partially supported by National Human Genome Research Institute, National Institute of health, PHS SPORE CA58236 (W.B.I), CA89600 (W.B.I., J.X.), CA95052 (J.X.), and a Department of Defense grant to J.X. There are no known conflicts of interest.",

year = "2005",

month = mar,

day = "10",

doi = "10.1016/j.canlet.2004.10.005",

language = "English (US)",

volume = "219",

pages = "177--182",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

AU - Chang, Bao Li

AU - Gillanders, Elizabeth M.

AU - Isaacs, Sarah D.

AU - Wiley, Kathy E.

AU - Adams, Tamara

AU - Turner, Aubrey R.

AU - Zheng, S. Lilly

AU - Meyers, Deborah A.

AU - Carpten, John D.

AU - Walsh, Patrick C.

AU - Trent, Jeffrey M.

AU - Xu, Jianfeng

AU - Isaacs, William B.

N1 - Funding Information: The authors thank all the study subjects who participated in this study. This work was partially supported by National Human Genome Research Institute, National Institute of health, PHS SPORE CA58236 (W.B.I), CA89600 (W.B.I., J.X.), CA95052 (J.X.), and a Department of Defense grant to J.X. There are no known conflicts of interest.

PY - 2005/3/10

Y1 - 2005/3/10

N2 - To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.

AB - To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.

KW - Cancer

KW - Genome-wide scan

KW - Hereditary

KW - Linkage

KW - Prostate cancer

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SN - 0304-3835

VL - 219

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EP - 182

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

Abstract

Keywords

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