Evaluation of intravenous flavopiridol formulations

Ping Li; Hemali Patel; S. Esmail Tabibi; Rao Vishnuvajjala; Samuel H. Yalkowsky

Evaluation of intravenous flavopiridol formulations

Ping Li
, Hemali Patel
, S. Esmail Tabibi
, Rao Vishnuvajjala
, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.

Original language	English (US)
Pages (from-to)	137-140
Number of pages	4
Journal	PDA Journal of Pharmaceutical Science and Technology
Volume	53
Issue number	3
State	Published - May 1999

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Evaluation of intravenous flavopiridol formulations",

abstract = "Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.",

author = "Ping Li and Hemali Patel and Tabibi, \{S. Esmail\} and Rao Vishnuvajjala and Yalkowsky, \{Samuel H.\}",

year = "1999",

month = may,

language = "English (US)",

volume = "53",

pages = "137--140",

journal = "PDA Journal of Pharmaceutical Science and Technology",

issn = "1079-7440",

publisher = "Parenteral Drug Association Inc.",

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T1 - Evaluation of intravenous flavopiridol formulations

AU - Li, Ping

AU - Patel, Hemali

AU - Tabibi, S. Esmail

AU - Vishnuvajjala, Rao

AU - Yalkowsky, Samuel H.

PY - 1999/5

Y1 - 1999/5

N2 - Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.

AB - Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.

UR - https://www.scopus.com/pages/publications/0032775898

UR - https://www.scopus.com/pages/publications/0032775898#tab=citedBy

M3 - Article

C2 - 10754703

AN - SCOPUS:0032775898

SN - 1079-7440

VL - 53

SP - 137

EP - 140

JO - PDA Journal of Pharmaceutical Science and Technology

JF - PDA Journal of Pharmaceutical Science and Technology

IS - 3

ER -

Evaluation of intravenous flavopiridol formulations

Abstract

ASJC Scopus subject areas

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