Abstract
Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-140 |
| Number of pages | 4 |
| Journal | PDA Journal of Pharmaceutical Science and Technology |
| Volume | 53 |
| Issue number | 3 |
| State | Published - May 1999 |
ASJC Scopus subject areas
- Pharmaceutical Science