Evaluation of Down-scatter Contamination in Multi-Pinhole 123I-IMP Brain Perfusion SPECT Imaging

Benjamin Auer, Jan De Beenhouwer, Kesava S. Kalluri, Clifford Lindsay, R. Garrett Richards, Micaehla May, Matthew A. Kupinski, Phillip H Kuo, Lars R. Furenlid, Michael A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Brain imaging with 123I radionuclide remains essential to assess the dopamine transporter activity or cerebral blood flow in various cerebral disorders. However, imaging with 123I-labeled tracers suffers from down-scatter contaminations from the emission of a series of high-energy (>183 keV, ~3% abundance) gamma photons in addition to the primary photons (159 keV, 83% abundance). In this work, we investigated through simulation studies the effect of down-scatter contamination on image quality using multiple pinhole configurations and aperture sizes of AdaptiSPECT-C, which is a next-generation multi-pinhole system currently under construction. We simulated a brain phantom with source distribution for the perfusion imaging agent 123I-IMP as imaged 1h post injection. To enable comparison of imaging without down-scatter interactions, reconstructions were compared qualitatively and quantitively to the ones obtained from acquisition of similar activity distribution simulated for solely the 159-keV principal emission of 123I. In this initial study, we demonstrated through quantification and visual inspection of cerebral perfusion reconstruction incorporating down-scatter correction that the inclusion of down-scatter counts does not hamper the imaging performance of AdaptiSPECT-C even for the pinhole combination the most contaminated by such interactions. We have initiated a comparison of these findings against the ones obtained from a dual-head system employing parallel-hole collimator for which acquisition is considerably more impacted by down-scatter interactions.

Original languageEnglish (US)
Title of host publication2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
EditorsHideki Tomita, Tatsuya Nakamura
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665421133
DOIs
StatePublished - 2021
Event2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021 - Virtual, Yokohama, Japan
Duration: Oct 16 2021Oct 23 2021

Publication series

Name2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022

Conference

Conference2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Country/TerritoryJapan
CityVirtual, Yokohama
Period10/16/2110/23/21

Keywords

  • I-IMP SPECT imaging
  • AdaptiSPECT-C
  • cerebral blood-flow perfusion
  • down-scatter contaminations
  • GATE Monte-Carlo simulation

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Health Informatics
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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