TY - GEN
T1 - Evaluation of Down-scatter Contamination in Multi-Pinhole 123I-IMP Brain Perfusion SPECT Imaging
AU - Auer, Benjamin
AU - De Beenhouwer, Jan
AU - Kalluri, Kesava S.
AU - Lindsay, Clifford
AU - Richards, R. Garrett
AU - May, Micaehla
AU - Kupinski, Matthew A.
AU - Kuo, Phillip H.
AU - Furenlid, Lars R.
AU - King, Michael A.
N1 - Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - Brain imaging with 123I radionuclide remains essential to assess the dopamine transporter activity or cerebral blood flow in various cerebral disorders. However, imaging with 123I-labeled tracers suffers from down-scatter contaminations from the emission of a series of high-energy (>183 keV, ~3% abundance) gamma photons in addition to the primary photons (159 keV, 83% abundance). In this work, we investigated through simulation studies the effect of down-scatter contamination on image quality using multiple pinhole configurations and aperture sizes of AdaptiSPECT-C, which is a next-generation multi-pinhole system currently under construction. We simulated a brain phantom with source distribution for the perfusion imaging agent 123I-IMP as imaged 1h post injection. To enable comparison of imaging without down-scatter interactions, reconstructions were compared qualitatively and quantitively to the ones obtained from acquisition of similar activity distribution simulated for solely the 159-keV principal emission of 123I. In this initial study, we demonstrated through quantification and visual inspection of cerebral perfusion reconstruction incorporating down-scatter correction that the inclusion of down-scatter counts does not hamper the imaging performance of AdaptiSPECT-C even for the pinhole combination the most contaminated by such interactions. We have initiated a comparison of these findings against the ones obtained from a dual-head system employing parallel-hole collimator for which acquisition is considerably more impacted by down-scatter interactions.
AB - Brain imaging with 123I radionuclide remains essential to assess the dopamine transporter activity or cerebral blood flow in various cerebral disorders. However, imaging with 123I-labeled tracers suffers from down-scatter contaminations from the emission of a series of high-energy (>183 keV, ~3% abundance) gamma photons in addition to the primary photons (159 keV, 83% abundance). In this work, we investigated through simulation studies the effect of down-scatter contamination on image quality using multiple pinhole configurations and aperture sizes of AdaptiSPECT-C, which is a next-generation multi-pinhole system currently under construction. We simulated a brain phantom with source distribution for the perfusion imaging agent 123I-IMP as imaged 1h post injection. To enable comparison of imaging without down-scatter interactions, reconstructions were compared qualitatively and quantitively to the ones obtained from acquisition of similar activity distribution simulated for solely the 159-keV principal emission of 123I. In this initial study, we demonstrated through quantification and visual inspection of cerebral perfusion reconstruction incorporating down-scatter correction that the inclusion of down-scatter counts does not hamper the imaging performance of AdaptiSPECT-C even for the pinhole combination the most contaminated by such interactions. We have initiated a comparison of these findings against the ones obtained from a dual-head system employing parallel-hole collimator for which acquisition is considerably more impacted by down-scatter interactions.
KW - AdaptiSPECT-C
KW - GATE Monte-Carlo simulation
KW - I-IMP SPECT imaging
KW - cerebral blood-flow perfusion
KW - down-scatter contaminations
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U2 - 10.1109/NSS/MIC44867.2021.9875469
DO - 10.1109/NSS/MIC44867.2021.9875469
M3 - Conference contribution
AN - SCOPUS:85139177300
T3 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
BT - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
A2 - Tomita, Hideki
A2 - Nakamura, Tatsuya
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Y2 - 16 October 2021 through 23 October 2021
ER -