Evaluation of autologous platelet rich plasma for cardiac surgery: Outcome analysis of 2000 patients

Amit N. Patel, Craig H. Selzman, Ganesh S. Kumpati, Stephen H. McKellar, David A. Bull

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Background: Deep and superficial sternal wound infections (DSWI & SWI) following cardiac surgery increase morbidity, mortality and cost. Autologous platelet rich plasma (PRP) derived from the patient's own blood has been used in other surgical settings to promote successful wound healing. The goal of this study was to analyze the addition of PRP using a rapid point of care bedside system to standard wound care in all patients undergoing sternotomy for cardiac surgical procedures. Methods: Over a 7 year period, 2000 patients undergoing open cardiac operations requiring sternotomy were enrolled. One thousand patients received standard of care sternal closure. The other 1000 patients received standard of care sternal closure plus PRP applied to the sternum at the time of closure. The outcomes related to wound healing, infection, readmissions, and costs were analyzed. Results: In the 2000 patients, there were more ventricular assist device implants/heart transplants and emergency operations in the PRP group; otherwise there were no significant differences. The use of PRP reduced the incidence of DSWI from 2.0 to 0.6 %, SWI from 8.0 to 2.0 %, and the readmission rate from 4.0 to 0.8 %. The use of PRP reduced the costs associated with the development of deep and superficial wound complications from $1,256,960 to $593,791. Conclusions: The use of PRP decreases the incidence and costs of sternal wound complications following cardiac surgery. The routine use of platelet rich plasma should be considered for all patients undergoing sternotomy for cardiac surgical procedures. Trial registration: Clinicaltrials.gov (NCT00130377 ) for the data registry.

Original languageEnglish (US)
Article number62
JournalJournal of Cardiothoracic Surgery
Volume11
Issue number1
DOIs
StatePublished - Apr 12 2016
Externally publishedYes

Keywords

  • Cardiac surgery
  • Infections
  • Platelets
  • Sternal
  • Wounds

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Evaluation of autologous platelet rich plasma for cardiac surgery: Outcome analysis of 2000 patients'. Together they form a unique fingerprint.

Cite this