Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Jeffrey W. Finch; Kevin A. Toerne; Karl H. Schram; M. Bonner Denton

doi:10.1002/rcm.1742

Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Jeffrey W. Finch, Kevin A. Toerne, Karl H. Schram, M. Bonner Denton

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A photoionization hydrogen laser time-of-flight mass spectrometer system (H₂-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H₂-TOFMS showed primarily intact molecular ions (M⁺) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.

Original language	English (US)
Pages (from-to)	15-22
Number of pages	8
Journal	Rapid Communications in Mass Spectrometry
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/rcm.1742
State	Published - 2005

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy
Organic Chemistry

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10.1002/rcm.1742

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abstract = "A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.",

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AU - Schram, Karl H.

AU - Denton, M. Bonner

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AB - A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.

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Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Abstract

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