Abstract
A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.
Original language | English (US) |
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Pages (from-to) | 15-22 |
Number of pages | 8 |
Journal | Rapid Communications in Mass Spectrometry |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - 2005 |
ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
- Organic Chemistry