Ethnic differences in asthma and associated phenotypes: Collaborative study on the genetics of asthma

Lucille A. Lester, Stephen S. Rich, Malcolm N. Blumenthal, Alkis Togias, Shirley Murphy, Floyd Malveaux, Michael E. Miller, Georgia M. Dunston, Julian Solway, Raoul L. Wolf, Jonathan M. Samet, David G. Marsh, Deborah A. Meyers, Carole Ober, Eugene R. Bleecker

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Background: In the Collaborative Study on the Genetics of Asthma, 314 families with 2584 subjects were characterized for asthma and allergy. Objective: The purpose of this investigation was to examine clinical heterogeneity observed in asthma and allergic characteristics among 3 ethnic groups (African American, white, and Hispanic family members). Methods: Pulmonary function parameters and asthma-associated phenotypes were compared among the ethnic groups. Results: In comparison with the other groups, African American sibling pairs had a significantly lower baseline FEV1percent of predicted (P =. 0001) and a higher rate of skin test reactivity to cockroach allergen (P =. 0001); Hispanic sibling pairs had significantly more skin reactivity overall (P =. 001); and white sibling pairs had significantly lower total serum IgE (P <.05). In addition, there were significantly more relatives with asthma among the African American families than among the white and the Hispanic families (P =. 001). Conclusion: Although different environmental backgrounds should be considered, these clinical differences could be due to differences in genetic susceptibility among the ethnic groups, such as those suggested by our previous genome screen.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Issue number3
StatePublished - Sep 2001
Externally publishedYes


  • Asthma
  • Atopy
  • Bronchial hyperresponsiveness
  • Ethnic differences

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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