Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause

Liqin Zhao, Zisu Mao, Lon S. Schneider, Roberta D. Brinton

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Objective: As an alternative to estrogen therapy, the efficacy of an estrogen receptor β-selective phytoestrogenic (phyto-β-SERM) formulation to regulate climacteric symptoms and decline in brain responses associated with ovarian hormone loss in menopause was assessed. Methods: A phyto-β-SERM formulation-containing diet was compared with a commercial soy extract diet and a phytoestrogen-free base/control diet in an ovariectomized (OVX) mouse model of human menopause. Two treatment studies were conducted: (1) a 2-month study assessed the effects of experimental diets on tail skin temperature as a model of menopausal hot flashes, and (2) a 9-month study assessed the long-term impact of the diets on overall health, hair thinning/loss, spatial working memory, and associated protein expression in the hippocampus. Results: The phyto-β-SERM diet prevented OVX-induced menopause-like changes including the rise in skin temperature, hair thinning/loss, deficit in spatial memory function, and reversed OVX-induced decline in the expression of hippocampal proteins involved in neural plasticity and β-amyloid degradation/clearance. The soy extract diet had no effect or exacerbated OVX-induced changes. Conclusions: Overall, the phyto-β-SERM diet induced physical and neurological responses comparable with ovary-intact mice, suggesting the therapeutic potential of the phyto-β-SERM formulation for the prevention/alleviation of climacteric symptoms and decline in brain responses induced by ovarian hormone loss, which provides the basis for further work in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1131-1142
Number of pages12
JournalMenopause
Volume18
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Cognition
  • Estrogen receptor β
  • Hair loss
  • Hot flashes
  • Menopause
  • Phytoestrogen

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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