Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds

Research output: Contribution to journalShort surveypeer-review

27 Scopus citations


Melting point, entropy of melting and heat capacity of melting are required for the calculation of the ideal solubility of a solid solute via the Clausius-Clapyron equation. This article reviews the published approximations of estimating entropy and heat capacity of melting. By comparing the available experimental results to calculated values the authors attempt to identify the best estimation of the ideal solubility and crystal-liquid fugacity ratio for organic compounds.

Original languageEnglish (US)
Pages (from-to)1100-1106
Number of pages7
JournalJournal of pharmaceutical sciences
Issue number3
StatePublished - Mar 2010


  • Crystallization
  • Crystals
  • Solid state
  • Solubility
  • Thermodynamics

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds'. Together they form a unique fingerprint.

Cite this