Abstract
Melting point, entropy of melting and heat capacity of melting are required for the calculation of the ideal solubility of a solid solute via the Clausius-Clapyron equation. This article reviews the published approximations of estimating entropy and heat capacity of melting. By comparing the available experimental results to calculated values the authors attempt to identify the best estimation of the ideal solubility and crystal-liquid fugacity ratio for organic compounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1100-1106 |
| Number of pages | 7 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2010 |
Keywords
- Crystallization
- Crystals
- Solid state
- Solubility
- Thermodynamics
ASJC Scopus subject areas
- Pharmaceutical Science