Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Na Ni; Mohamed M. El-Sayed; Tapan Sanghvi; Samuel H Yalkowsky

doi:10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.0.CO;2-N

Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Na Ni, Mohamed M. El-Sayed, Tapan Sanghvi, Samuel H Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	1620-1625
Number of pages	6
Journal	Journal of pharmaceutical sciences
Volume	89
Issue number	12
DOIs	https://doi.org/10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.0.CO;2-N
State	Published - 2000

Keywords

Nonelectrolyte
Partition coefficient
Setschenow constant
Sodium chloride
Solubility

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.0.CO;2-N

Cite this

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title = "Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions",

abstract = "The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.",

keywords = "Nonelectrolyte, Partition coefficient, Setschenow constant, Sodium chloride, Solubility",

author = "Na Ni and El-Sayed, {Mohamed M.} and Tapan Sanghvi and Yalkowsky, {Samuel H}",

year = "2000",

doi = "10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.0.CO;2-N",

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TY - JOUR

T1 - Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

AU - Ni, Na

AU - El-Sayed, Mohamed M.

AU - Sanghvi, Tapan

AU - Yalkowsky, Samuel H

PY - 2000

Y1 - 2000

N2 - The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

AB - The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

KW - Nonelectrolyte

KW - Partition coefficient

KW - Setschenow constant

KW - Sodium chloride

KW - Solubility

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JO - Journal of pharmaceutical sciences

JF - Journal of pharmaceutical sciences

IS - 12

ER -

Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Abstract

Keywords

ASJC Scopus subject areas

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