TY - JOUR
T1 - Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions
AU - Ni, Na
AU - El-Sayed, Mohamed M.
AU - Sanghvi, Tapan
AU - Yalkowsky, Samuel H.
PY - 2000
Y1 - 2000
N2 - The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.
AB - The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.
KW - Nonelectrolyte
KW - Partition coefficient
KW - Setschenow constant
KW - Sodium chloride
KW - Solubility
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U2 - 10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.3.CO;2-E
DO - 10.1002/1520-6017(200012)89:12<1620::AID-JPS13>3.3.CO;2-E
M3 - Article
C2 - 11042610
AN - SCOPUS:0033636811
SN - 0022-3549
VL - 89
SP - 1620
EP - 1625
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 12
ER -