Estimation of the aqueous solubility of weak electrolytes

Neera Jain, Gang Yang, Stephen G. Machatha, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Jain and Yalkowsky [Jain, N., Yalkowsky, S.H., 2001. Estimation of the aqueous solubility. I. Application to organic non-electrolytes. J. Pharm. Sci. 90, 234-252.] demonstrated that the general solubility equation (GSE) can be used to estimate the aqueous solubility of organic non-electrolytes. In this study the applicability of the GSE was extended to weak electrolytes. It is demonstrated that the GSE estimates the aqueous solubility of 949 compounds, including 367 weak electrolytes with an AAE of 0.58. It is also shown that the intrinsic solubilities of weak acids for which the pKa + log Sw ≤ 0 and for weak bases for which pKa - log Sw ≤ 14 are within a factor of 2 of the total solubilities.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalInternational Journal of Pharmaceutics
Issue number1-2
StatePublished - Aug 17 2006


  • GSE
  • Solubility
  • Weak electrolytes
  • pKa

ASJC Scopus subject areas

  • Pharmaceutical Science


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