Estimation of the aqueous solubility I: Application to organic nonelectrolytes

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324 Scopus citations


The estimation of aqueous solubilities of organic nonelectrolytes by the General Solubility Equation (GSE) as proposed by Valvani and Yalkowsky (1980) is used in this study. The data and assumptions on which the GSE are based are reevaluated, and the equation is revised. The revised GSE is validated on a set of 580 pharmaceutically, environmentally, and industrially relevant nonelectrolytes. The revised equation has a stronger theoretical background and provides a more accurate estimation of aqueous solubility.

Original languageEnglish (US)
Pages (from-to)234-252
Number of pages19
JournalJournal of pharmaceutical sciences
Issue number2
StatePublished - 2001


  • Estimation
  • Nonelectrolytes
  • Partitioning
  • Solubility

ASJC Scopus subject areas

  • Pharmaceutical Science


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