Abstract
The entropy of fusion for many drugs and molecules of intermediate size can be estimated in the following manner: (1) for rigid molecules, ΔS, 13.5 eu; (2) for long chain derivatives of such molecules, AS, 13.5 ± 2.5(n - 5) eu, where n is the number of flexible links in the chain. In most cases, these simple rules will provide an estimate of AS, which is sufficiently accurate to obtain reasonable estimates of ideal solubility.
Original language | English (US) |
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Pages (from-to) | 108-111 |
Number of pages | 4 |
Journal | Industrial and Engineering Chemistry Fundamentals |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - May 1 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- General Engineering