Estimating the Aqueous Solubility of Pharmaceutical Hydrates

Stephen J. Franklin, Usir S. Younis, Paul B. Myrdal

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Estimation of crystalline solute solubility is well documented throughout the literature. However, the anhydrous crystal form is typically considered with these models, which is not always the most stable crystal form in water. In this study, an equation which predicts the aqueous solubility of a hydrate is presented. This research attempts to extend the utility of the ideal solubility equation by incorporating desolvation energetics of the hydrated crystal. Similar to the ideal solubility equation, which accounts for the energetics of melting, this model approximates the energy of dehydration to the entropy of vaporization for water. Aqueous solubilities, dehydration and melting temperatures, and log P values were collected experimentally and from the literature. The data set includes different hydrate types and a range of log P values. Three models are evaluated, the most accurate model approximates the entropy of dehydration (ΔSd) by the entropy of vaporization (ΔSvap) for water, and utilizes onset dehydration and melting temperatures in combination with log P. With this model, the average absolute error for the prediction of solubility of 14 compounds was 0.32 log units.

Original languageEnglish (US)
Pages (from-to)1914-1919
Number of pages6
JournalJournal of pharmaceutical sciences
Issue number6
StatePublished - Jun 1 2016


  • dehydration
  • hydrates/solvates
  • log P
  • mathematical model
  • solubility

ASJC Scopus subject areas

  • Pharmaceutical Science


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