Erratum: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain (PLoS Genetics (2015) 11:10 (e1005591) DOI: 10.1371/journal.pgen.1005591)

There are errors in Figs 4A and 9A and S2A, and in the primer sequences listed for Acer2 and Acer3 in the 'RNA extraction and qPCR' section of the Materials and Methods. The authors apologize for the errors and provide further details and corrections below. In Fig 4A, an incorrect pair of primers was used to amplify the whole open reading frame of the Acer3 gene. The correct primer pair is 5'-ATGGCTCCGGCTGTGGACC-3'/5'-TCAGTG CTTCCTCTGAGGTTCAAAC-3'. The authors have redone the experiment with the correct primer pair, and have provided a corrected Fig 4. In Fig 9A, the histology panel of the Acer3 knockout mouse (Acer3-/-) for the 6W timepoint is duplicated. The histology panel has been corrected in the new Fig 9. In S2A Fig, the wild-type (Acer3+/+) panel is duplicated for the 12M timepoints. The correct Acer3 knockout (Acer3-/-) panel is provided in the revised S2 Fig. The primer sequences listed for Acer2 and Acer3 in the 'RNA extraction and qPCR' section of the Materials and Methods are duplicated. The correct primer sequences for Acer3 are 5'-GATTCACTGAGGAACTTTCG-3'/5'-AGAGAAACTTCACTTTTGGC-3'. The primer sequences for Acer2 are correct. The underlying spreadsheet data for the graphs and bar charts in the figures is not included in the published article, and is available as S1 Dataset. (Figure Presented).