Abstract
In an effort to gain insights into the inception and course of allergic diseases, the role of epigenetic processes, primarily DNA methylation, is actively being explored. Indeed, epigenetic mechanisms guide developmental programs, regulate gene expression independently of changes to the DNA sequence, and offer the plasticity to respond to environmental stimuli, factors known to influence allergic disease pathogenesis. To date, most studies have characterized relationships between DNA methylation and concurrent disease, but whether disease-associated methylation profiles are a cause or consequence of the disease is difficult to decipher. A growing body of work is now exploring whether DNA methylation profiles at birth influence subsequent disease trajectories. These studies are the primary, albeit not the only, focus of this review.
Original language | English (US) |
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Title of host publication | Epigenetics of the Immune System |
Publisher | Elsevier |
Pages | 269-283 |
Number of pages | 15 |
ISBN (Electronic) | 9780128179642 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Childhood allergic disease
- Childhood asthma
- DNA methylation
- Epigenetics
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology