Epidermal Ia molecules from the I-A and I-EC subregions of the mouse H-2 complex

John G. Frelinger; Peter J. Wettstein; Jeffrey A. Frelinger; Leroy Hood

doi:10.1007/BF01563903

Epidermal Ia molecules from the I-A and I-EC subregions of the mouse H-2 complex

John G. Frelinger, Peter J. Wettstein, Jeffrey A. Frelinger, Leroy Hood

Immunobiology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Immune response region-associated (Ia) antigens encoded by genes in the I-A or I-EC subregions have been detected on murine epidermal cells by indirect immunoprecipitation, using antisera produced against murine lymphoid cells. The Ia antigens encoded by genes in these subregions are composed of two polypeptides with approximate molecular weights of 33,000 and 28,000. The Ia antigens are not derived from contaminating B- or T-cell populations. The Ia molecules from lymphocytes and epidermal cells appear to have identical subunit structures and very similar, if not identical, molecular weights. The possible biological role of the Ia antigens on epidermal cells is discussed.

Original language	English (US)
Pages (from-to)	125-135
Number of pages	11
Journal	Immunogenetics
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/BF01563903
State	Published - Dec 1978

ASJC Scopus subject areas

Immunology
Genetics

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title = "Epidermal Ia molecules from the I-A and I-EC subregions of the mouse H-2 complex",

abstract = "Immune response region-associated (Ia) antigens encoded by genes in the I-A or I-EC subregions have been detected on murine epidermal cells by indirect immunoprecipitation, using antisera produced against murine lymphoid cells. The Ia antigens encoded by genes in these subregions are composed of two polypeptides with approximate molecular weights of 33,000 and 28,000. The Ia antigens are not derived from contaminating B- or T-cell populations. The Ia molecules from lymphocytes and epidermal cells appear to have identical subunit structures and very similar, if not identical, molecular weights. The possible biological role of the Ia antigens on epidermal cells is discussed.",

author = "Frelinger, {John G.} and Wettstein, {Peter J.} and Frelinger, {Jeffrey A.} and Leroy Hood",

year = "1978",

month = dec,

doi = "10.1007/BF01563903",

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T1 - Epidermal Ia molecules from the I-A and I-EC subregions of the mouse H-2 complex

AU - Frelinger, John G.

AU - Wettstein, Peter J.

AU - Frelinger, Jeffrey A.

AU - Hood, Leroy

PY - 1978/12

Y1 - 1978/12

N2 - Immune response region-associated (Ia) antigens encoded by genes in the I-A or I-EC subregions have been detected on murine epidermal cells by indirect immunoprecipitation, using antisera produced against murine lymphoid cells. The Ia antigens encoded by genes in these subregions are composed of two polypeptides with approximate molecular weights of 33,000 and 28,000. The Ia antigens are not derived from contaminating B- or T-cell populations. The Ia molecules from lymphocytes and epidermal cells appear to have identical subunit structures and very similar, if not identical, molecular weights. The possible biological role of the Ia antigens on epidermal cells is discussed.

AB - Immune response region-associated (Ia) antigens encoded by genes in the I-A or I-EC subregions have been detected on murine epidermal cells by indirect immunoprecipitation, using antisera produced against murine lymphoid cells. The Ia antigens encoded by genes in these subregions are composed of two polypeptides with approximate molecular weights of 33,000 and 28,000. The Ia antigens are not derived from contaminating B- or T-cell populations. The Ia molecules from lymphocytes and epidermal cells appear to have identical subunit structures and very similar, if not identical, molecular weights. The possible biological role of the Ia antigens on epidermal cells is discussed.

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ER -

Epidermal Ia molecules from the I-A and I-EC subregions of the mouse H-2 complex

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