TY - JOUR
T1 - Epidemiology of cannabidiol related cases reported in the National Poison Data System – 2019-2020
AU - Berger, Brandon A.
AU - Stolz, Uwe
AU - Colvin, Jonathan
AU - Otten, Edward J.
N1 - Funding Information:
Thank you to staff of the Cincinnati Drug and Poison Information Center, as well as Nathaniel Pham, MS and Kristen Toth, MS at the American Association of Poison Control Centers for their assistance in data acquisition.
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: Cannabidiol (CBD) has become a popular supplement in consumer products in recent years, resulting in part from normalization of the cultivation of low THC cannabis in 2018. However, the actual content of CBD-labeled products is frequently uncertain, as oversight of such products is minimal. To date, there is little pragmatic knowledge regarding exposures to products labeled as containing CBD. Methods: Cases reported to Poison Control Centers from April 1, 2019 and March 31, 2020, the first year in which CBD was identified uniquely as a substance in the National Poison Data System, were analyzed for demographic, temporal, and clinical trends. Results: Poison Control Centers handled 1581 cases exposures to CBD-containing products between April 1, 2019 and March 31, 2020. There was a significant trend of over 5 additional cases related to this substance per month (linear regression coefficient = 5.2, 95% CI: 1.52–8.98). Patients under age 13 years made up 44.0% of reported exposures. Mild CNS depression (10.3%), tachycardia (5.7%), dizziness/vertigo (5.3%), vomiting (4.9%), nausea (4.5%), and agitation (4.4%) were the most frequently reported symptoms. 13% of cases were coded as having “moderate” or “severe” medical outcomes. There were no fatalities. Conclusions: Cases reported to Poison Control Centers regarding exposures to CBD-labeled products have been increasing, representing an emerging trend of interest to Poison Control Center professionals, clinicians, and public health officials. Further monitoring of this trend is recommended.
AB - Introduction: Cannabidiol (CBD) has become a popular supplement in consumer products in recent years, resulting in part from normalization of the cultivation of low THC cannabis in 2018. However, the actual content of CBD-labeled products is frequently uncertain, as oversight of such products is minimal. To date, there is little pragmatic knowledge regarding exposures to products labeled as containing CBD. Methods: Cases reported to Poison Control Centers from April 1, 2019 and March 31, 2020, the first year in which CBD was identified uniquely as a substance in the National Poison Data System, were analyzed for demographic, temporal, and clinical trends. Results: Poison Control Centers handled 1581 cases exposures to CBD-containing products between April 1, 2019 and March 31, 2020. There was a significant trend of over 5 additional cases related to this substance per month (linear regression coefficient = 5.2, 95% CI: 1.52–8.98). Patients under age 13 years made up 44.0% of reported exposures. Mild CNS depression (10.3%), tachycardia (5.7%), dizziness/vertigo (5.3%), vomiting (4.9%), nausea (4.5%), and agitation (4.4%) were the most frequently reported symptoms. 13% of cases were coded as having “moderate” or “severe” medical outcomes. There were no fatalities. Conclusions: Cases reported to Poison Control Centers regarding exposures to CBD-labeled products have been increasing, representing an emerging trend of interest to Poison Control Center professionals, clinicians, and public health officials. Further monitoring of this trend is recommended.
KW - Cannabidiol
KW - Cannabis sativa
KW - CBD
KW - National Poison Data System
KW - Poison control center
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U2 - 10.1016/j.ajem.2021.04.065
DO - 10.1016/j.ajem.2021.04.065
M3 - Article
C2 - 33975134
AN - SCOPUS:85105592163
SN - 0735-6757
VL - 48
SP - 218
EP - 223
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
ER -