Epidemiology of cannabidiol related cases reported in the National Poison Data System – 2019-2020

Brandon A. Berger, Uwe Stolz, Jonathan Colvin, Edward J. Otten

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Introduction: Cannabidiol (CBD) has become a popular supplement in consumer products in recent years, resulting in part from normalization of the cultivation of low THC cannabis in 2018. However, the actual content of CBD-labeled products is frequently uncertain, as oversight of such products is minimal. To date, there is little pragmatic knowledge regarding exposures to products labeled as containing CBD. Methods: Cases reported to Poison Control Centers from April 1, 2019 and March 31, 2020, the first year in which CBD was identified uniquely as a substance in the National Poison Data System, were analyzed for demographic, temporal, and clinical trends. Results: Poison Control Centers handled 1581 cases exposures to CBD-containing products between April 1, 2019 and March 31, 2020. There was a significant trend of over 5 additional cases related to this substance per month (linear regression coefficient = 5.2, 95% CI: 1.52–8.98). Patients under age 13 years made up 44.0% of reported exposures. Mild CNS depression (10.3%), tachycardia (5.7%), dizziness/vertigo (5.3%), vomiting (4.9%), nausea (4.5%), and agitation (4.4%) were the most frequently reported symptoms. 13% of cases were coded as having “moderate” or “severe” medical outcomes. There were no fatalities. Conclusions: Cases reported to Poison Control Centers regarding exposures to CBD-labeled products have been increasing, representing an emerging trend of interest to Poison Control Center professionals, clinicians, and public health officials. Further monitoring of this trend is recommended.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalAmerican Journal of Emergency Medicine
StatePublished - Oct 2021
Externally publishedYes


  • Cannabidiol
  • Cannabis sativa
  • CBD
  • National Poison Data System
  • Poison control center

ASJC Scopus subject areas

  • Emergency Medicine


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