TY - JOUR
T1 - Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children
AU - Madico, Guillermo
AU - McDonald, Jeffrey
AU - Gilman, Robert H.
AU - Cabrera, Lilia
AU - Sterling, Charles R.
N1 - Funding Information:
Received 10 June 1996; revised 25 September 1996. Verbal consent was obtained from the subject's guardian or the subject. This study was approved by the ethics committees of The Johns Hopkins University and the Universidad Peruana Cayetano Heredia. Financial support: This study was supported in part by the RG-ER fund and the National Institutes of Health (1-001 AI35894-0l). Reprints or correspondence: Dr. Robert H. Gilman, Department of International Health, The Johns Hopkins School of Hygiene and Public Health, Room 5521, 615 Wolfe Street, Baltimore, Maryland 21205.
PY - 1997
Y1 - 1997
N2 - Cyclospora cayetanensis was detected in fecal specimens from 63 (1.1%) of 5,836 Peruvian children studied over 2 years; the protozoan was detected by modified acid-fast staining and autofluorescence under ultraviolet light. The highest prevalence occurred among children between 2 and 4 years of age. Thirty-two percent (20) of the 63 C. cayetanensis-infected children were symptomatic. Nineteen infected children were enrolled in a double-blind, placebo-controlled trial of a 3-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 5/25 mg/[kg·d]). Children were followed up with daily stool examinations (mean number of samples examined per child ± SE, 19 ± 4). The mean duration of oocyst excretion ± SE was 4.8 ± 1.2 days for TMP-SMZ recipients compared with 12.1 ± 6.1 days for placebo recipients (P < .02). The prevalence of C. cayetanensis infection decreases during winter months and as children age; it decreases precipitously by adulthood. In children in areas of endemicity, C. cayetanensis usually causes mild disease that is often asymptomatic. TMP-SMZ therapy significantly decreases the duration of oocyst excretion.
AB - Cyclospora cayetanensis was detected in fecal specimens from 63 (1.1%) of 5,836 Peruvian children studied over 2 years; the protozoan was detected by modified acid-fast staining and autofluorescence under ultraviolet light. The highest prevalence occurred among children between 2 and 4 years of age. Thirty-two percent (20) of the 63 C. cayetanensis-infected children were symptomatic. Nineteen infected children were enrolled in a double-blind, placebo-controlled trial of a 3-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 5/25 mg/[kg·d]). Children were followed up with daily stool examinations (mean number of samples examined per child ± SE, 19 ± 4). The mean duration of oocyst excretion ± SE was 4.8 ± 1.2 days for TMP-SMZ recipients compared with 12.1 ± 6.1 days for placebo recipients (P < .02). The prevalence of C. cayetanensis infection decreases during winter months and as children age; it decreases precipitously by adulthood. In children in areas of endemicity, C. cayetanensis usually causes mild disease that is often asymptomatic. TMP-SMZ therapy significantly decreases the duration of oocyst excretion.
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U2 - 10.1093/clinids/24.5.977
DO - 10.1093/clinids/24.5.977
M3 - Article
C2 - 9142805
AN - SCOPUS:0030893862
SN - 1058-4838
VL - 24
SP - 977
EP - 981
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -