TY - JOUR
T1 - Eosinophil-associated lung diseases
T2 - A cry for surfactant proteins A and D help?
AU - Ledford, Julie G.
AU - Addison, Kenneth J.
AU - Foster, Matthew W.
AU - Que, Loretta G.
N1 - Publisher Copyright:
Copyright © 2014 by the American Thoracic Society.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.
AB - Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.
KW - Collectin
KW - Eosinophil
KW - Surfactant
KW - Surfactant protein-A
KW - Surfactant protein-D
UR - http://www.scopus.com/inward/record.url?scp=84914117749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84914117749&partnerID=8YFLogxK
U2 - 10.1165/rcmb.2014-0095TR
DO - 10.1165/rcmb.2014-0095TR
M3 - Review article
C2 - 24960334
AN - SCOPUS:84914117749
SN - 1044-1549
VL - 51
SP - 604
EP - 614
JO - American journal of respiratory cell and molecular biology
JF - American journal of respiratory cell and molecular biology
IS - 5
ER -