Environmental Toxicology Assays Using Organ-on-Chip

Patarajarin Akarapipad, Kattika Kaarj, Yan Liang, Jeong Yeol Yoon

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Adverse effects of environmental toxicants to human health have traditionally been assayed using in vitro assays. Organ-on-chip (OOC) is a new platform that can bridge the gaps between in vitro assays (or 3D cell culture) and animal tests. Microenvironments, physical and biochemical stimuli, and adequate sensing and biosensing systems can be integrated into OOC devices to better recapitulate the in vivo tissue and organ behavior and metabolism. While OOCs have extensively been studied for drug toxicity screening, their implementation in environmental toxicology assays is minimal and has limitations. In this review, recent attempts of environmental toxicology assays using OOCs, including multiple-organs-on-chip, are summarized and compared with OOC-based drug toxicity screening. Requirements for further improvements are identified and potential solutions are suggested.

Original languageEnglish (US)
Pages (from-to)155-183
Number of pages29
JournalAnnual Review of Analytical Chemistry
StatePublished - 2021


  • Biosensors
  • Cell-based assays
  • Environmental toxicants
  • In vitro assays
  • Multiple-organs-on-chip

ASJC Scopus subject areas

  • Analytical Chemistry


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