TY - JOUR
T1 - Environmental Toxicology Assays Using Organ-on-Chip
AU - Akarapipad, Patarajarin
AU - Kaarj, Kattika
AU - Liang, Yan
AU - Yoon, Jeong Yeol
N1 - Publisher Copyright:
Copyright © 2021 by Annual Reviews. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Adverse effects of environmental toxicants to human health have traditionally been assayed using in vitro assays. Organ-on-chip (OOC) is a new platform that can bridge the gaps between in vitro assays (or 3D cell culture) and animal tests. Microenvironments, physical and biochemical stimuli, and adequate sensing and biosensing systems can be integrated into OOC devices to better recapitulate the in vivo tissue and organ behavior and metabolism. While OOCs have extensively been studied for drug toxicity screening, their implementation in environmental toxicology assays is minimal and has limitations. In this review, recent attempts of environmental toxicology assays using OOCs, including multiple-organs-on-chip, are summarized and compared with OOC-based drug toxicity screening. Requirements for further improvements are identified and potential solutions are suggested.
AB - Adverse effects of environmental toxicants to human health have traditionally been assayed using in vitro assays. Organ-on-chip (OOC) is a new platform that can bridge the gaps between in vitro assays (or 3D cell culture) and animal tests. Microenvironments, physical and biochemical stimuli, and adequate sensing and biosensing systems can be integrated into OOC devices to better recapitulate the in vivo tissue and organ behavior and metabolism. While OOCs have extensively been studied for drug toxicity screening, their implementation in environmental toxicology assays is minimal and has limitations. In this review, recent attempts of environmental toxicology assays using OOCs, including multiple-organs-on-chip, are summarized and compared with OOC-based drug toxicity screening. Requirements for further improvements are identified and potential solutions are suggested.
KW - Biosensors
KW - Cell-based assays
KW - Environmental toxicants
KW - In vitro assays
KW - Multiple-organs-on-chip
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U2 - 10.1146/annurev-anchem-091620-091335
DO - 10.1146/annurev-anchem-091620-091335
M3 - Review article
C2 - 33974806
AN - SCOPUS:85111693811
SN - 1936-1327
VL - 14
SP - 155
EP - 183
JO - Annual Review of Analytical Chemistry
JF - Annual Review of Analytical Chemistry
ER -