TY - JOUR
T1 - Environmental protection from allergic diseases
T2 - From humans to mice and back
AU - Schaub, Bianca
AU - Vercelli, Donata
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Allergic diseases have a strong environmental component, illustrated by the rapid rise of their prevalence in the Western world. Environmental exposures have been consistently shown to either promote or protect against allergic disease. Here we focus on protective exposures and the pathways they regulate. Traditional farming, natural environments with high biodiversity, and pets in the home (particularly dogs) have the most potent and consistent allergy-protective effects and are actively investigated to identify the environmental and host-based factors that confer allergy protection. Recent work emphasizes the critical protective role of microbial diversity and its interactions with the gut/lung and skin/lung axes. -. a cross-talk through which microbial exposure in the gut or skin powerfully influences immune responses in the lung.
AB - Allergic diseases have a strong environmental component, illustrated by the rapid rise of their prevalence in the Western world. Environmental exposures have been consistently shown to either promote or protect against allergic disease. Here we focus on protective exposures and the pathways they regulate. Traditional farming, natural environments with high biodiversity, and pets in the home (particularly dogs) have the most potent and consistent allergy-protective effects and are actively investigated to identify the environmental and host-based factors that confer allergy protection. Recent work emphasizes the critical protective role of microbial diversity and its interactions with the gut/lung and skin/lung axes. -. a cross-talk through which microbial exposure in the gut or skin powerfully influences immune responses in the lung.
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U2 - 10.1016/j.coi.2015.07.004
DO - 10.1016/j.coi.2015.07.004
M3 - Review article
C2 - 26210896
AN - SCOPUS:84937825768
SN - 0952-7915
VL - 36
SP - 88
EP - 93
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -