Environmental arsenic exposure and urinary 8-OHdG in Arizona and Sonora

Jefferey L. Burgess, Maria M. Meza, Arun B. Josyula, Gerald S. Poplin, Michael J. Kopplin, Hannah E. McClellen, Stefan Stürup, R. Clark Lantz

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Although at high levels arsenic exposure is associated with increased cancer incidence, information on the health effects of lower exposure levels is limited. The objective of this study was to determine whether arsenic at concentrations below 40 μg/L in drinking water is associated with increased urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage and repair. Urine samples were collected from 73 nonsmoking adults residing in two communities in Arizona (mean tap water arsenic (μg/L) 4.0 ± 2.3 and 20.3 ± 3.7), and 51 subjects in four communities in Sonora, Mexico (mean tap water arsenic (μg/L) ranging from 4.8 ± 0.1 to 33.3 ± 0.6). Although urinary arsenic concentration increased with higher exposure in tap water, urinary 8-OHdG concentration did not differ by community within Arizona or Sonora, and was not associated with urinary arsenic concentration. At the exposure levels evaluated in this study, drinking water arsenic was not associated with increased DNA oxidation as measured by urinary 8-OHdG.

Original languageEnglish (US)
Pages (from-to)490-498
Number of pages9
JournalClinical Toxicology
Issue number5
StatePublished - Jul 2007


  • 8-OHdG
  • Arizona
  • Arsenic
  • Sonora
  • Urine
  • Water

ASJC Scopus subject areas

  • Toxicology


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