Environmental arsenic exposure and serum matrix metalloproteinase-9

Jefferey L. Burgess, Margaret Kurzius-Spencer, Mary Kay O'Rourke, Sally R. Littau, Jason Roberge, Maria Mercedes Meza-Montenegro, Luis Enrique Gutiérrez-Millán, Robin B. Harris

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The objective of this study was to evaluate the relationship between environmental arsenic exposure and serum matrix metalloproteinase (MMP)-9, a biomarker associated with cardiovascular disease and cancer. In a cross-sectional study of residents of Arizona, USA (n=215) and Sonora, Mexico (n=163), drinking water was assayed for total arsenic, and daily drinking water arsenic intake was estimated. Urine was speciated for arsenic, and concentrations were adjusted for specific gravity. Serum was analyzed for MMP-9 using ELISA. Mixed model linear regression was used to assess the relation among drinking water arsenic concentration, drinking water arsenic intake, urinary arsenic sum of species (the sum of arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid), and MMP-9, controlling for autocorrelation within households. Drinking water arsenic concentration and intake were positively associated with MMP-9, both in crude analysis and after adjustment for gender, country/ethnicity, age, body mass index, current smoking, and diabetes. Urinary arsenic sum of species was positively associated with MMP-9 in multivariable analysis only. Using Akaike's Information Criterion, arsenic concentration in drinking water provided a better fitting model of MMP-9 than either urinary arsenic or drinking water arsenic intake. In conclusion, arsenic exposure evaluated using all three exposure metrics was positively associated with MMP-9.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalJournal of Exposure Science and Environmental Epidemiology
Issue number2
StatePublished - Mar 2013


  • arsenic
  • binational study
  • drinking water
  • matrix metalloproteinase-9
  • urine

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health


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