@article{6ceea1370804430f8fb663389b3eec9d,
title = "Enhanced serological and virological findings of epstein-barr virus in patients with aids and aids-related complex",
abstract = "The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoprolifer- ative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDS- related complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lympho- tropic virus type III, suggest that EBV may have a contributory role in these disorders.",
author = "Sumaya, {Ciro Valent} and Boswell, {Richard Neal} and Yasmin Ench and Kisner, {Daniel L.} and Hersh, {Evan M.} and Reuben, {James M.} and Peter, {Peter W.} and Sumaya, {Ciro Valent} and Boswell, {Richard Neal} and Yasmin Ench and Kisner, {Daniel L.} and Hersh, {Evan M.} and Reuben, {James M.} and Peter, {Peter W.} and Sumaya, {Ciro Valent} and Boswell, {Richard Neal} and Yasmin Ench and Kisner, {Daniel L.} and Hersh, {Evan M.} and Reuben, {James M.} and Peter, {Peter W.}",
note = "Funding Information: Received for publication 14 January 1986, and in revised form 12 June 1986. Informed consent was obtained from the subjects in this study according to the guidelines of each participating institution. The views expressed herein are those of the author(s) and do not necessarily reflect the opinions of the United States Air Force or of the Department of Defense. This work was supported in part by grants CA-37477 and CA-34674 from the National Cancer Institute. We thank Ruth LaPushin for assistance in collecting specimens. Please address requests for reprints to Dr. Ciro Valent Sumaya, Department of Pediatrics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284.",
year = "1986",
month = nov,
day = "1",
doi = "10.1093/infdis/154.5.864",
language = "English (US)",
volume = "154",
pages = "864--870",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}