Enhanced serological and virological findings of epstein-barr virus in patients with aids and aids-related complex

Ciro Valent Sumaya, Richard Neal Boswell, Yasmin Ench, Daniel L. Kisner, Evan M. Hersh, James M. Reuben, Peter W. Peter

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoprolifer- ative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDS- related complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lympho- tropic virus type III, suggest that EBV may have a contributory role in these disorders.

Original languageEnglish (US)
Pages (from-to)864-870
Number of pages7
JournalJournal of Infectious Diseases
Volume154
Issue number5
DOIs
StatePublished - Nov 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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