Enhanced endoscopic detection of early colon cancer

Gowri Balachandar, Eugene A. Trowers

Research output: Contribution to journalConference articlepeer-review


Enhanced endoscopic detection of small flat adenomas is becoming increasingly important as they have a reported 14% incidence of dysplasia when compared with 5% incidence in polypoid adenomas of the same size. These lesions even when invasive do not show up against the translucent surrounding mucosa making endoscopic detection difficult. Dye spraying with indigo carmine makes their morphology clear, with well-circumscribed borders. Dye spraying and magnifying endoscopes can be used to observe pit patterns on the surface of the bowel. Combining dye spraying and high-resolution video endoscopy demonstrates well the colorectal epithelial surface. Scanning immersion video endoscopy visualizes the epithelial surface of the colorectal mucosa by high-resolution endoscopy after filling the lumen with water. Endoscopic ultrasound can be used to see if the lesion is intramucosal or not and assess the depth of invasion if malignancy is present. Laser-induced fluorescence spectroscopy has the potential to detect colonic dysplasia in vivo. Combining such technologies with conventional colonoscopy can help in the surveillance of large areas of colonic mucosa for the presence of dysplasia. Guided biopsy can replace random biopsy based on information provided at the time of colonoscopic examination.

Original languageEnglish (US)
Pages (from-to)412-419
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
EventProceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 24 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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