Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation

R. S. Hill, P. Mazza, D. Amos, C. D. Buckner, F. R. Appelbaum, P. Matin, B. J. Still, S. Sica, R. Berenson, W. Bensinger, R. A. Clift, P. Stewart, K. Doney, J. Sanders, J. Singer, K. M. Sullivan, R. P. Whiterspoon, R. Storb, R. Livingston

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The kinetics of marrow engraftment was retrospectively analysed in 55 patients with malignant lymphoma (ML) and 31 patients with aucte lymphoblastic leukemia (ALL) after marrow-ablative therapy followed by autologous bone marrow transplantation. Thirty-eight percent of patients with ML, most of whom were transplanted in relapse and 13% of patients with ALL, mostly transplanted in remission, showed failed or delayed engraftment. Analysis of the total patient group showed that failure to recover platelet counts was significantly correlated with detection of disease in the marrow early after transplantation (p < 0.001). Platelet recovery was also correlated with survival (p = 0.0001), disease-free survival (p = 0.0001), and the probability of relapse (p = 0.02). In those patients achieving engraftment, multivariate regression analysis failed to reveal any single in vitro test of marrow nucleated cell or progenitor cell numbers that significantly influenced time to achieve recovery of either granulocyte or platelet counts.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalBone Marrow Transplantation
Issue number1
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Transplantation


Dive into the research topics of 'Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation'. Together they form a unique fingerprint.

Cite this