Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo

Daniel B. Carr, Richard Bergland, Allan Hamilton, Howard Blume, Norman Kasting, Michael Arnold, Joseph B. Martin, Michael Rosenblatt

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.

Original languageEnglish (US)
Pages (from-to)845-848
Number of pages4
Issue number4562
StatePublished - 1982

ASJC Scopus subject areas

  • General


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